Peer-reviewed Article
MixtureTree: A program for constructing phylogeny
Abstract
Background
MixtureTree v1.0 is a Linux based program (written in C++) which implements an algorithm based on mixture models for reconstructing phylogeny from binary sequence data, such as single-nucleotide polymorphisms (SNPs). In addition to the mixture algorithm with three different optimization options, the program also implements a bootstrap procedure with majority-rule consensus.
Results
The MixtureTree program written in C++ is a Linux based package. The User's Guide and source codes will be available at http://math.asu.edu/~scchen/MixtureTree.html
Conclusions
The efficiency of the mixture algorithm is relatively higher than some classical methods, such as Neighbor-Joining method, Maximum Parsimony method and Maximum Likelihood method. The shortcoming of the mixture tree algorithms, for example timing consuming, can be improved by implementing other revised Expectation-Maximization(EM) algorithms instead of the traditional EM algorithm.
Full Citation
Chen, S.-C., M.S. Rosenberg, and B.G. Lindsay (2011) MixtureTree: A program for constructing phylogeny. BMC Bioinformatics 12:111. [3 pages]
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PMID: 21615972
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